Article
Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain
2018-08-31
Abstract excerpt
Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. In this study, we analyzed the RNA expression patterns of more than 76,000 individual microglia during development, old age and after brain injury. Analysis uncovered at least nine transcriptionally distinct microglial states...
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Identifiers and source
- Literature Corpus work
- 84f3dfa5-02b1-5e9e-bfed-0209cc55afb2
- DOI
- 10.1101/406140