Article

Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk

2025-09-02

Abstract excerpt

To systematically identify causal genetic mechanisms that confer risk for coronary artery disease (CAD) in GWAS loci, we mapped genome-wide variant-to-enhancer-to-gene (V2E2G) links in vascular smooth muscle cells (SMC). Enhancers identified by active chromatin features, and further prioritized by base-resolution deep learning models of chromatin accessibility in 108 CAD loci, were studied with CRISPRi targeting a...

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Literature Corpus work: a24b4bd4-574a-5348-a90f-0b6806fcc96f
DOI: 10.1101/2025.08.28.25334684

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