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Article

Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci.

Molecular systems biology - 1 Nov 2025

Weldy Chad S, Kundu Soumya, Monteiro João, Gu Wenduo, Pedroza Albert J, Dalal Alex R, Worssam Matthew D, Li Daniel, Palmisano Brian, Zhao Quanyi, Sharma Disha, Nguyen Trieu, Kundu Ramendra, Fischbein Michael P, Engreitz Jesse, Kundaje Anshul B, Cheng Paul P, Quertermous Thomas

Abstract excerpt

Vascular sites have distinct susceptibility to atherosclerosis and aneurysm, yet the epigenomic and transcriptomic underpinning of vascular site-specific disease risk is largely unknown. Here, we performed single-cell chromatin accessibility (scATACseq) and gene expression profiling (scRNAseq) of mouse vascular tissue from three vascular sites. Through interrogation of epigenomic enhancers and gene regulatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40931195
DOI: 10.1038/s44320-025-00140-2
PMCID: PMC12583710

Genes

HAND2
SMAD3
TF

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