Article

CAD variants act through ox-LDL-induced enhancer remodelling to alter VSMC gene programmes

2026-04-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Vascular smooth muscle cells (VSMCs) play a central role in atherosclerotic coronary artery disease (CAD). Oxidised low-density lipoprotein cholesterol (ox-LDL) induces VSMCs dysfunction but the underlying molecular mechanisms are unclear. CAD genome-wide association studies (GWAS) have identified hundreds of disease-associated loci but their biological roles remain poorly d...

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Literature Corpus work: 4e7285bf-9e1c-5ccc-97ab-6af3c26b2caf
DOI: 10.64898/2026.04.21.718843

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