Article

Large-scale discovery of recombinases for integrating DNA into the human genome

2021-11-06

Abstract excerpt

<h4>SUMMARY</h4> Recent microbial genome sequencing efforts have revealed a vast reservoir of mobile genetic elements containing integrases that could be useful genome engineering tools. Large serine recombinases (LSRs), such as Bxb1 and PhiC31, are bacteriophage-encoded integrases that can facilitate the insertion of phage DNA into bacterial genomes. However, only a few LSRs have been previously characterized an...

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Literature Corpus work: a0b000cb-da9c-53fc-adcb-5489ae066708
DOI: 10.1101/2021.11.05.467528

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