Article

Randomizing the human genome by engineering recombination between repeat elements

2024-01-23

Abstract excerpt

While protein-coding genes are characterized increasingly well, 99% of the human genome is non-coding and poorly understood. This gap is due to a lack of tools for engineering variants that affect sequence to the necessary extent. To bridge this gap, we have developed a toolbox to create deletions, inversions, translocations, and extrachromosomal circular DNA at scale by highly multiplexed insertion of recombinase...

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Identifiers and source

Literature Corpus work: 42e808a1-7519-5be7-9c71-6dd0315b8a07
DOI: 10.1101/2024.01.22.576745

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