Article

S-SELeCT: A Human-Evolved Serine Integrase System for Efficient Large-Cargo Genome Integration

2026-02-01

Abstract excerpt

<h4>ABSTRACT</h4> As a consequence of their sizes, many loss-of-function genetic mutations fall within large genes. A major gene-therapy tool that could be used to solve large swaths of the genetic diseases that result from these inherited mutations is large-fragment knock-in. I.e. instead of attempting to create separate treatments for each and every location that these mutations occur in, large groups of patien...

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Literature Corpus work: 8b9bc996-d4fd-59f6-9ba4-5be244cf4baf
DOI: 10.64898/2026.01.30.702954

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