Article

Reprogrammed Serine Integrases Enable Precise Integration of Synthetic DNA

2024-05-10

Abstract excerpt

<h4>Summary</h4> Despite recent progress in the ability to manipulate the genomes of eukaryotic cells 1–3 , there is still no effective and practical method to precisely integrate large synthetic DNA constructs into desired chromosomal sites using a programmable integrase. Serine integrases can perform the necessary molecular steps 4 , but only if their natural target site is first installed into the recipient...

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Literature Corpus work: a782cb89-27f7-548a-8764-e259e1af0004
DOI: 10.1101/2024.05.09.593242

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