Article

Programmable large DNA deletion, replacement, integration, and inversion with twin prime editing and site-specific recombinases

2021-11-02

Abstract excerpt

<h4>Summary</h4> The targeted deletion, replacement, integration, or inversion of DNA sequences at specified locations in the genome could be used to study or treat many human genetic diseases. Here, we describe twin prime editing (twinPE), a method for the programmable replacement or excision of DNA sequence at endogenous human genomic sites without requiring double-strand DNA breaks. TwinPE uses a prime editor...

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Literature Corpus work: beb9af36-250f-530e-b20a-cf9dae6556c6
DOI: 10.1101/2021.11.01.466790

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