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Article

Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome.

PloS one - 1 Jan 2015

Wallen Mark C, Gaj Thomas, Barbas Carlos F

Abstract excerpt

Site-specific recombinases (SSRs) are valuable tools for genetic engineering due to their ability to manipulate DNA in a highly specific manner. Engineered zinc-finger and TAL effector recombinases, in particular, are two classes of SSRs composed of custom-designed DNA-binding domains fused to a catalytic domain derived from the resolvase/invertase family of serine recombinases. While TAL effector and zinc-finger...

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Share to Catalytic Domain
Share to Genetic Loci
Share to Genome, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, CCR5

Share to Recombinases

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Source

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Identifiers

PMID: 26414179
DOI: 10.1371/journal.pone.0139123
PMCID: PMC4587366

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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