Article

Mutational Scanning of α-Synuclein using a Clickable Protein Tag Reveals Determinants of Membrane-Induced Aggregation

2026-04-23

Abstract excerpt

The cellular environment plays a critical role in shaping protein conformations, including aggregated states implicated in disease. One challenge to studying this relationship is that most techniques offering high-resolution insight into the nature of these aggregates cannot be deployed in living cells. Systematic mutagenesis presents an opportunity to bridge this gap but requires general and robust methods to det...

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Literature Corpus work: 9fbd23c4-07c0-5051-92e5-03a53c29da27
DOI: 10.64898/2026.04.20.719647

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