Article

Concentration-Dependent Mutational Scanning Probes the Cellular Folding Landscape of <i>α</i> -Synuclein in Yeast

2025-08-30

Abstract excerpt

The misfolding and aggregation of α-synuclein is a central molecular event in the etiology of Parkinson’s disease and related disorders. α-Synuclein misfolding and pathology are both concentration-dependent, but it is not clear precisely how changes in concentration alter the folding landscape within cells. Whereas most conventional structural biology approaches offer limited resolution in living systems, deep mut...

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Literature Corpus work: 22f1f0e3-d7ef-5462-9aec-9190e2a3ab5d
DOI: 10.1101/2025.08.29.672156

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