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Article

Deep mutational scanning reveals the structural basis for α-synuclein activity.

Nature chemical biology - 1 Jun 2020

Newberry Robert W, Leong Jaime T, Chow Eric D, Kampmann Martin, DeGrado William F

Abstract excerpt

Defining the biologically active structures of proteins in their cellular environments remains challenging for proteins with multiple conformations and functions, where only a minor conformer might be associated with a given function. Here, we use deep mutational scanning to probe the structure and dynamics of α-synuclein, a protein known to adopt disordered, helical and amyloid conformations. We examined the...

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Identifiers

PMID: 32152544
DOI: 10.1038/s41589-020-0480-6
PMCID: PMC7339969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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