Article

Probing the energy landscape of α-Synuclein amyloid fibril formation by systematic K-to-Q mutagenesis

2025-11-03

Abstract excerpt

The aggregation of natively disordered α-Synuclein (αSyn) into amyloid fibrils is a hallmark of Parkinson’s and other neurodegenerative diseases. Understanding αSyn’s pathological role remains a major challenge due to its complex, context-dependent energy landscape characterized by conformational plasticity and fibril polymorphism. Here, we present a systematic mutational analysis as a quantitative probe of the αS...

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Literature Corpus work: 75fe0d0e-47b9-5fcc-8650-9717a60a6979
DOI: 10.1101/2025.11.01.685997

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