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Article

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

ACS chemical biology - 16 Sept 2016

Dikiy Igor, Fauvet Bruno, Jovičić Ana, Mahul-Mellier Anne-Laure, Desobry Carole, El-Turk Farah, Gitler Aaron D, Lashuel Hilal A, Eliezer David

Abstract excerpt

Alpha-synuclein is a presynaptic protein of poorly understood function that is linked to both genetic and sporadic forms of Parkinson's disease. We have proposed that alpha-synuclein may function specifically at synaptic vesicles docked at the plasma membrane, and that the broken-helix state of the protein, comprising two antiparallel membrane-bound helices connected by a nonhelical linker, may target the protein...

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Identifiers

PMID: 27356045
DOI: 10.1021/acschembio.6b00539
PMCID: PMC5240779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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