Article

Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding

2020-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in living cells. Here, we use deep mutational scanning to investigate how a toxic conformation of α-synuclein, a dynamic protein linked to Parkinson’s...

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Literature Corpus work: 84ac44ee-5951-5de6-a2b7-903b661a070f
DOI: 10.1101/2020.05.01.072884

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