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Article

The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly.

Journal of neurochemistry - 1 Apr 2023

Brontesi Lisa, Imberdis Thibaut, Ramalingam Nagendran, Dettmer Ulf

Abstract excerpt

Alpha-synuclein (αS), the key protein in Parkinson's disease, is typically described as an intrinsically disordered protein. Consistent with this notion, several context-dependent folding states may coexist in neurons. Unfolded soluble monomers, helical monomers at membranes and helical multimers (soluble or at membranes) have all been reported and may be in an equilibrium with each other. We previously found...

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Identifiers

PMID: 36625497
DOI: 10.1111/jnc.15763
PMCID: PMC10211470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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