Article
Aggregation prone regions and gatekeeping residues in protein sequences.
Current topics in medicinal chemistry - 1 Jan 2012
Beerten Jacinte, Schymkowitz Joost, Rousseau Frederic
Abstract excerpt
Most protein sequences contain one or several short aggregation prone regions (APR) that can nucleate protein aggregation. Under normal conditions these APRs are protected from aggregation by protein interactions or because they are buried in the hydrophobic core of native protein domains. However, mutation, physiological stress or age-related disregulation of protein homeostasis increases the probability that...
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