Article
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.
ACS chemical biology - 21 Aug 2020
Newberry Robert W, Arhar Taylor, Costello Jean, Hartoularos George C, Maxwell Alison M, Naing Zun Zar Chi, Pittman Maureen, Reddy Nishith R, Schwarz Daniel M C, Wassarman Douglas R, Wu Taia S, Barrero Daniel, Caggiano Christa, Catching Adam, Cavazos Taylor B, Estes Laurel S, Faust Bryan, Fink Elissa A, Goldman Miriam A, Gomez Yessica K, Gordon M Grace, Gunsalus Laura M, Hoppe Nick, Jaime-Garza Maru, Johnson Matthew C, Jones Matthew G, Kung Andrew F, Lopez Kyle E, Lumpe Jared, Martyn Calla, McCarthy Elizabeth E, Miller-Vedam Lakshmi E, Navarro Erik J, Palar Aji, Pellegrino Jenna, Saylor Wren, Stephens Christina A, Strickland Jack, Torosyan Hayarpi, Wankowicz Stephanie A, Wong Daniel R, Wong Garrett, Redding Sy, Chow Eric D, DeGrado William F, Kampmann Martin
Abstract excerpt
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in living cells. Here, we use deep mutational scanning to investigate how a toxic conformation of α-synuclein, a dynamic protein linked to Parkinson's disease, responds...
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