Article

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

2022-06-09

Abstract excerpt

Aggregation of α-Synuclein (α-Syn) drives Parkinson’s disease, although the initial stages of self-assembly and structural conversion have not been captured inside neurons. We track the intracellular conformational states of α-Syn utilizing a single-molecule FRET biosensor, and show that α-Syn converts from its monomeric state to form two distinct oligomeric states in neurons in a concentration dependent, and sequ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11b601e0-f8b0-5441-bb05-87b6c9faa6de
DOI: 10.1101/2022.06.07.494932

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicityDOI 10.1101/2022.06.07.494932Read

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.Semantic proximity Read

α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology.Semantic proximity Read

Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications.Semantic proximity Read

Change in the Oligomeric State of α-Synuclein Variants in Living Cells.Semantic proximity Read

Alpha-synuclein fibrils induce budding of mitochondrial-derived vesiclesSemantic proximity Read

Initiation and progression of α-synuclein pathology in Parkinson’s diseaseSemantic proximity Read

An automated workflow for quantifying the formation of synuclein aggregates in human dopaminergic neuronsSemantic proximity Read

Self-limiting multimerization of α-synuclein on membrane and its implication in Parkinson's diseases.Semantic proximity Read

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson’s DiseaseSemantic proximity Read

Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and DiseaseSemantic proximity Read

Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson’s diseaseSemantic proximity Read

Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging.Semantic proximity Read