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Article

Concentration-dependent mutational scanning probes the cellular folding landscape of α-synuclein in yeast.

Protein science : a publication of the Protein Society - 1 Feb 2026

Noh Daeun, Newberry Robert W

Abstract excerpt

The misfolding and aggregation of α-synuclein is a central molecular event in the etiology of Parkinson's disease and related disorders. α-synuclein misfolding and pathology are both concentration-dependent, but it is not clear precisely how changes in concentration alter the folding landscape within cells. Whereas most conventional structural biology approaches offer limited resolution in living systems, deep...

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PMID: 41556620
DOI: 10.1002/pro.70456
PMCID: PMC12817481

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