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Article

Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease

25 Sept 2018

Abstract excerpt

α-Synuclein (αS) is a conserved and abundant neuronal protein with unusual structural properties. It appears to partition between folded and unstructured states as well as between membrane-bound and aqueously soluble states. In addition, a switch between monomeric and tetrameric/multimeric states has been observed recently. The precise composition, localization and abundance of the multimeric species are under...

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PMID: 30319334
DOI: 10.3389/fnins.2018.00623

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