Article

The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice

2026-08-05

Abstract excerpt

<h4>Background</h4> Inflammation is an early event that substantially influences Alzheimer’s disease (AD) pathogenesis, making it a compelling target for therapeutic intervention. Sob-AM2 is a brain-penetrating thyromimetic drug capable of inducing the expression of microglial cell surface receptor TREM2, which mediates the switch from pro-inflammatory to a more restorative microglial state. <h4>Objective</h4> E...

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Literature Corpus work: 9fa4d6bc-f134-5641-b8bf-1e9d1d1511d8
DOI: 10.64898/2026.07.31.741838

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