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Article

Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2014

Jiang Teng, Tan Lan, Zhu Xi-Chen, Zhang Qiao-Quan, Cao Lei, Tan Meng-Shan, Gu Li-Ze, Wang Hui-Fu, Ding Zheng-Zheng, Zhang Ying-Dong, Yu Jin-Tai

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2) gene is a recently identified susceptibility gene for Alzheimer's disease (AD), as its low-frequency variants increase the risk of this disease with an odds ratio similar to that of an APOE ɛ4 allele. To date, the expression and biologic functions of TREM2 under AD context remain largely unknown. Using APPswe/PS1dE9 mice, a transgenic model of AD, we showed...

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Identifiers

PMID: 25047746
DOI: 10.1038/npp.2014.164
PMCID: PMC4229581

Genes

TREM2
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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