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Article

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.

The Journal of experimental medicine - 5 Mar 2018

Song Wilbur M, Joshita Satoru, Zhou Yingyue, Ulland Tyler K, Gilfillan Susan, Colonna Marco

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disease that causes late-onset dementia. The R47H variant of the microglial receptor TREM2 triples AD risk in genome-wide association studies. In mouse AD models, TREM2-deficient microglia fail to proliferate and cluster around the amyloid-β plaques characteristic of AD. In vitro, the common variant (CV) of TREM2 binds anionic lipids, whereas R47H mutation impairs...

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Identifiers

PMID: 29321225
DOI: 10.1084/jem.20171529
PMCID: PMC5839761

Genes

TREM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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