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Article

Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease.

The Lancet. Neurology - 1 Nov 2023

Schlepckow Kai, Morenas-Rodríguez Estrella, Hong Soyon, Haass Christian

Abstract excerpt

Neurodegenerative disorders, including Alzheimer's disease, are associated with microgliosis. Microglia have long been considered to have detrimental roles in Alzheimer's disease. However, functional analyses of genes encoding risk factors that are linked to late-onset Alzheimer's disease, and that are enriched or exclusively expressed in microglia, have revealed unexpected protective functions. One of the major...

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PMID: 37863592
DOI: 10.1016/S1474-4422(23)00247-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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