Article

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer’s Models

2026-01-21

Abstract excerpt

Triggering receptor expressed on myeloid cells-2 (TREM2) is a key immune receptor in the central nervous system that regulates microglial phagocytosis, survival, and neuroinflammatory responses. TRME2 variants have been established as genetic risk factors for Alzheimer’s disease (AD). However, the therapeutic development of TREM2 modulators has been limited to antibody-based approaches that face limitations in blo...

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Literature Corpus work: a2df9b54-80a3-5696-b9a8-3b3f3f1f0c6f
DOI: 10.64898/2026.01.19.700278

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