Article

BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice

2023-08-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Genetic study of late-onset Alzheimer’s disease (AD) reveals that a rare Arginine-to-Histamine mutation at amino acid residue 47 (R47H) in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) results in increased disease risk. TREM2 plays critical roles in regulating microglial response to amyloid plaques in AD, leading to their clustering and activation surrounding the...

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Literature Corpus work: 1ca0fcfe-ca41-501b-bff5-1cc42a7bbd12
DOI: 10.1101/2023.08.03.551881

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