Article

Structural and functional analysis of TREM2 interactions with amyloid beta reveal molecular mechanisms that mediate phagocytosis of oligomeric amyloid beta

2024-05-25

Abstract excerpt

The TREM2 receptor is expressed on microglia in the brain, where it plays critical roles regulating microglia function. TREM2 engages a number of ligands involved in Alzheimer’s disease, and consequent signaling triggers phagocytosis, activation, survival, and proliferation. TREM2 has emerged as a drug target for AD, however very little is known regarding the structural basis for TREM2 microglial functions. Here w...

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Literature Corpus work: bcbc63e5-c4f0-569a-b191-bb7bd86772ff
DOI: 10.1101/2024.05.23.595586

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