Article
Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology.
Journal of neuroinflammation - 10 Dec 2021
Sheng Xuan, Yao Yunling, Huang Ruizhi, Xu Ying, Zhu Yifei, Chen Linting, Zhang Lianshuai, Wang Wanbing, Zhuo Rengong, Can Dan, Chang Che-Feng, Zhang Yun-Wu, Xu Huaxi, Bu Guojun, Zhong Li, Chen Xiao-Fen
Abstract excerpt
BACKGROUND: TREM2 is a microglial receptor genetically linked to the risk for Alzheimer's disease (AD). The cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2) have emerged as a valuable biomarker for the disease progression in AD and higher CSF levels of sTREM2 are linked to slower cognitive decline. Increasing sTREM2 in mouse models of amyloidosis reduces amyloid-related pathology through modulating...
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