Article
Soluble TREM2 induces inflammatory responses and enhances microglial survival.
The Journal of experimental medicine - 6 Mar 2017
Zhong Li, Chen Xiao-Fen, Wang Tingting, Wang Zhe, Liao Chunyan, Wang Zongqi, Huang Ruizhi, Wang Daxin, Li Xinxiu, Wu Linbei, Jia Lin, Zheng Honghua, Painter Meghan, Atagi Yuka, Liu Chia-Chen, Zhang Yun-Wu, Fryer John D, Xu Huaxi, Bu Guojun
Abstract excerpt
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed in microglia in the brain. A soluble form of TREM2 (sTREM2) derived from proteolytic cleavage of the cell surface receptor is increased in the preclinical stages of AD and positively correlates with the amounts of total and phosphorylated tau in the cerebrospinal fluid. However, the physiological and pathological...
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