Article
Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
Neuron - 7 Mar 2018
Lee C Y Daniel, Daggett Anthony, Gu Xiaofeng, Jiang Lu-Lin, Langfelder Peter, Li Xiaoguang, Wang Nan, Zhao Yingjun, Park Chang Sin, Cooper Yonatan, Ferando Isabella, Mody Istvan, Coppola Giovanni, Xu Huaxi, Yang X William
Abstract excerpt
Variants of TREM2 are associated with Alzheimer's disease (AD). To study whether increasing TREM2 gene dosage could modify the disease pathogenesis, we developed BAC transgenic mice expressing human TREM2 (BAC-TREM2) in microglia. We found that elevated TREM2 expression reduced amyloid burden in the 5xFAD mouse model. Transcriptomic profiling demonstrated that increasing TREM2 levels conferred a rescuing effect,...
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