Article
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Cell - 12 Mar 2015
Wang Yaming, Cella Marina, Mallinson Kaitlin, Ulrich Jason D, Young Katherine L, Robinette Michelle L, Gilfillan Susan, Krishnan Gokul M, Sudhakar Shwetha, Zinselmeyer Bernd H, Holtzman David M, Cirrito John R, Colonna Marco
Abstract excerpt
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor that triggers intracellular protein tyrosine phosphorylation. Recent genome-wide association studies have shown that a rare R47H mutation of TREM2 correlates with a substantial increase in the risk of developing Alzheimer's disease (AD). To address the basis for this genetic association, we studied TREM2 deficiency in the...
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