Article

AI-Assisted Discovery and Optimization of Small Molecule TREM2 Agonists with Functional Microglial Activity

2025-09-17

Abstract excerpt

<h4>ABSTRACT</h4> Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor whose loss-of-function variants increase Alzheimer’s disease (AD) risk by impairing plaque compaction, survival, and protective microglial programming. While antibody-based agonists have shown promise, their translation is hindered by poor brain penetration and high cost. Here, we report the discovery and o...

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Literature Corpus work: ae638332-341e-5793-99f0-ca6b672d2c5c
DOI: 10.1101/2025.09.11.675743

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