Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative disease

Abstract excerpt

<h4>ABSTRACT</h4> Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) results in the engraftment of genetically modified microglia-like cells (MLCs) in the brain. While HSPC-GT has shown a clear neurological benefit in the clinic for specific rare diseases, the nature of MLC engraftment in the brain and the functional characteristics of MLCs remain contentious. Here we comprehensively characterized how diff...

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• Adenosine and Purinergic Signaling
• Amyotrophic Lateral Sclerosis Research
• Long-Term Effects of COVID-19
• Lysosomal Storage Disorders Research
• Mesenchymal stem cell research
• Neurogenesis and neuroplasticity mechanisms
• Neuroinflammation and Neurodegeneration Mechanisms

Identifiers and source

Literature Corpus work

fe7fa9d4-9ea2-544b-9bf5-f87622e2872e

DOI

10.1101/2021.09.16.460703