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A novel glia-immune humanized mouse model for investigating neuroimmune mechanisms in CNS HIV infection and diverse neurological disorders

2025-03-11

Abstract excerpt

Dysregulation in neuroimmune interactions drives pathology in diverse neurological disorders. However, human cell-based in vivo models are limited for clinically relevant mechanistic studies and drug testing. To address this, we developed a novel humanized mouse model integrating all four major types of human glia - astrocytes, oligodendrocyte precursor cells (OPCs), oligodendrocytes, and microglia - in the brain,...

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Literature Corpus work
09702988-a828-5af7-92d6-c7b12d765088
DOI
10.1101/2025.03.05.641678
Open publication

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A novel glia-immune humanized mouse model for investigating neuroimmune mechanisms in CNS HIV infection and diverse neurological disordersDOI 10.1101/2025.03.05.641678
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