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Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids

2023-10-25

Abstract excerpt

<h4>ABSTRACT</h4> Human immunodeficiency virus type-1 (HIV-1) associated neurocognitive disorder (HAND) affects up to half of HIV-1 positive patients with long term neurological consequences, including dementia. There are no effective therapeutics for HAND because the pathophysiology of HIV-1 induced glial and neuronal functional deficits in humans remains enigmatic. To bridge this knowledge gap, we established a...

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Literature Corpus work
c30eb1be-625d-5e10-881e-809a6bb84c79
DOI
10.1101/2023.10.25.563950
Open publication

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Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoidsDOI 10.1101/2023.10.25.563950
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