Article

Comparative Analysis of Human Microglial Models for Studies of HIV Replication and Pathogenesis

2020-10-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>HIV associated neurocognitive disorders cause significant morbidity and mortality despite the advent of highly active antiretroviral therapy. A deeper understanding of fundamental mechanisms underlying HIV infection and pathogenesis in the central nervous system is warranted. Microglia are resident myeloid cells of the brain that are readily infected by HIV and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c6cebfb-7772-5b96-ab5e-b2fe1fe04faa
DOI: 10.21203/rs.3.rs-41442/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative Analysis of Human Microglial Models for Studies of HIV Replication and PathogenesisDOI 10.21203/rs.3.rs-41442/v2Read

Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analysesSemantic proximity Read

HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)Semantic proximity Read

HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microgliaSemantic proximity Read

Human microglia phenotypes in the brain associated with HIV infection.Semantic proximity Read

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaquesSemantic proximity Read

Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoidsSemantic proximity Read

Investigation of CNS damage following HIV infection and methamphetamine exposure using human iPSC-derived microglia and 3D cerebral assembloid modelsSemantic proximity Read

Transcriptional Mapping of Neuro-Immune Interactions during Homeostasis and HIV infection using Microglia-containing Human Cerebral AssembloidsSemantic proximity Read

Single cell RNA sequencing reveals a novel, microglia-like cell type in cerebrospinal fluid during virologically suppressed HIVSemantic proximity Read

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaquesSemantic proximity Read

Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain TissueSemantic proximity Read

HIV-1 infection promotes neuroinflammation and neuron pathogenesis in novel microglia-containing cerebral organoidsSemantic proximity Read