Article

HIV-1 infection promotes neuroinflammation and neuron pathogenesis in novel microglia-containing cerebral organoids

2024-06-14

Abstract excerpt

Cerebral organoids (COs) are a valuable tool to study the intricate interplay between glial cells and neurons in brain development and disease, including HIV-associated neuroinflammation. We developed a novel approach to generate microglia containing COs (CO-iMs) by co-culturing hematopoietic progenitors and induced pluripotent stem cells. This approach allowed for the differentiation of microglia within the organ...

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Literature Corpus work: 0945fead-f1dc-5e14-b9e3-8143524df5bf
DOI: 10.1101/2024.06.13.598579

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