Article

Exercise Reprograms PHGDH Spatial Function: A Metabolic Switch Governing Neurodegeneration via Brain-Periphery Crosstalk

2026-02-27

Abstract excerpt

Therapeutic stagnation in Alzheimer’s disease (AD) highlights the role of non-genetic mechanisms like metabolic dysregulation. We propose a paradigm: exercise reprograms phosphoglycerate dehydrogenase (PHGDH) from a pathogenic nuclear transcription factor to a protective cytoplasmic metabolic enzyme through brain-periphery crosstalk. Under AD-associated stress, PHGDH translocate to the nucleus, where its helix-tur...

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Literature Corpus work: 9e118e88-1566-57f9-a829-37ac025b276c
DOI: 10.20944/preprints202602.1857.v1

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