Article

Therapeutic targeting of immunometabolism in Alzheimer’s disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression

2023-11-15

Abstract excerpt

<h4>Summary</h4> Microgliosis and neuroinflammation are prominent features of Alzheimer’s disease (AD). Disease-responsive microglia meet their increased energy demand by reprogramming metabolism, specifically, switching to favor glycolysis over oxidative phosphorylation. Thus, targeting of microglial immunometabolism might be of therapeutic benefit for treating AD, providing novel and often well understood immun...

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Literature Corpus work: f38f3ddf-882a-5c84-a667-ef60b670d701
DOI: 10.1101/2023.11.11.566270

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Therapeutic targeting of immunometabolism in Alzheimer’s disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progressionDOI 10.1101/2023.11.11.566270Read

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