Article
Not just correlative: a new pathway defines how an ALDH2 SNP contributes to atherosclerosis.
The Journal of clinical investigation - 2 Jan 2019
Gibb Andrew A, Elrod John W
Abstract excerpt
Individuals with the rs671 SNP in the gene encoding aldehyde dehydrogenase 2 (ALDH2) are at increased risk of cardiovascular disease (CVD); however, it has been unclear if this mutation contributes to CVD development. In this issue of the JCI, Zhong et al. perform an elegant set of experiments that reveal a pathway wherein the ALDH2 rs671 mutant is phosphorylated by AMPK and translocates to the nucleus where it...
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