Unraveling the Influence of HHEX Risk Polymorphism rs7923837 on Multiple Sclerosis Pathogenesis.

doi:10.3390/ijms23147956

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Article

Unraveling the Influence of HHEX Risk Polymorphism rs7923837 on Multiple Sclerosis Pathogenesis.

International journal of molecular sciences - 19 Jul 2022

González-Jiménez Adela, López-Cotarelo Pilar, Agudo-Jiménez Teresa, Martínez-Ginés Marisa, García-Domínguez Jose Manuel, Urcelay Elena, Espino-Paisán Laura

Abstract excerpt

One of the multiple sclerosis (MS) risk polymorphisms, rs7923837, maps near the HHEX (hematopoietically-expressed homeobox) gene. This variant has also been associated with type 2 diabetes susceptibility and with triglyceride levels, suggesting its metabolic involvement. HHEX plays a relevant role as a negative regulator of inflammatory genes in microglia. A reciprocal repression was reported between HHEX and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35887298
DOI: 10.3390/ijms23147956
PMCID: PMC9321666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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