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Article

Exercise hormone irisin is a critical regulator of cognitive function.

Nature metabolism - 1 Aug 2021

Islam Mohammad R, Valaris Sophia, Young Michael F, Haley Erin B, Luo Renhao, Bond Sabrina F, Mazuera Sofia, Kitchen Robert R, Caldarone Barbara J, Bettio Luis E B, Christie Brian R, Schmider Angela B, Soberman Roy J, Besnard Antoine, Jedrychowski Mark P, Kim Hyeonwoo, Tu Hua, Kim Eunhee, Choi Se Hoon, Tanzi Rudolph E, Spiegelman Bruce M, Wrann Christiane D

Abstract excerpt

Identifying secreted mediators that drive the cognitive benefits of exercise holds great promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here, we show that irisin, the cleaved and circulating form of the exercise-induced membrane protein FNDC5, is sufficient to confer the benefits of exercise on cognitive function. Genetic deletion of Fndc5/irisin (global Fndc5 knock-out (KO)...

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Identifiers

PMID: 34417591
DOI: 10.1038/s42255-021-00438-z
PMCID: PMC10317538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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