Article

Irisin mediates exercise-induced glymphatic α-synuclein clearance by upregulating astrocytic REV-ERBα in Parkinson’s disease

2026-04-30

Abstract excerpt

<title>Abstract</title> <p>Physical exercise alleviates motor deficits and neuropathology in Parkinson’s disease (PD), yet the underlying mechanisms remain elusive. Using a mouse model induced by α-synuclein (αSyn) preformed fibrils, we found that glymphatic transport was markedly impaired in PD mice, accompanied by disrupted perivascular aquaporin-4 (AQP4) polarization and αSyn accumulation. Chronic treadmill ex...

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Literature Corpus work: afe4ada1-44fc-5ebc-9bb9-5111e01ebd5f
DOI: 10.21203/rs.3.rs-9467573/v1

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