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Article

ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy.

Signal transduction and targeted therapy - 24 Jul 2020

Wang Shuyi, Wang Lin, Qin Xing, Turdi Subat, Sun Dongdong, Culver Bruce, Reiter Russel J, Wang Xiaoming, Zhou Hao, Ren Jun

Abstract excerpt

Ample clinical evidence suggests a high incidence of cardiovascular events in Alzheimer's disease (AD), although neither precise etiology nor effective treatment is available. This study was designed to evaluate cardiac function in AD patients and APP/PS1 mutant mice, along with circulating levels of melatonin, mitochondrial aldehyde dehydrogenase (ALDH2) and autophagy. AD patients and APP/PS1 mice displayed...

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Share to Adaptor Proteins, Signal Transducing
Share to Aldehyde Dehydrogenase, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Heart Defects, Congenital

Share to Melatonin

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Source

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Identifiers

PMID: 32703954
DOI: 10.1038/s41392-020-0171-5
PMCID: PMC7378833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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