Article

Selective reduction of <i>KCNA4</i> in vulnerable glutamatergic-serotonin neurons of the dorsal raphe nucleus in Alzheimer’s Disease

2025-10-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> We previously demonstrated that htau mice recapitulate many neuropsychiatric features of early Alzheimer’s disease (AD), and that the dorsal raphe nucleus (DRN) contains distinct subregions. Herein, we investigate vulnerability of the centromedial DRN to pathologically-phosphorylated tau (pTau), a region composed predominantly of dually serotonergic/glutamatergic (5HT/glut...

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Literature Corpus work: 2320b9f6-8ac6-59c3-aaf9-dfd96d794334
DOI: 10.1101/2025.10.17.683113

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Selective reduction of <i>KCNA4</i> in vulnerable glutamatergic-serotonin neurons of the dorsal raphe nucleus in Alzheimer’s DiseaseDOI 10.1101/2025.10.17.683113Read

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