Article

Adipose GPD2 Couples Glycolytic Signals to Epigenetic Control of Metabolic Homeostasis

2026-07-20

Abstract excerpt

The glycerol-3-phosphate shuttle (G3PS) is a classic reducing equivalent transferring system, yet its role in adipose metabolism remains poorly understood. Here, we identify mitochondrial glycerol-3-phosphate dehydrogenase (GPD2), the core enzyme of G3PS, as a critical orchestrator of adipose thermogenesis and systemic metabolic homeostasis. Adipocyte-specific GPD2 knockout mice exhibited impaired thermogenic capa...

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Literature Corpus work: f367114d-8356-5518-8e20-3dec6e1282a1
DOI: 10.64898/2026.07.19.739432

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