Article

Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson's disease via histone lactylation

2023-08-17

Abstract excerpt

<title>Abstract</title> <p>The metabolic switch from oxidative phosphorylation to glycolysis is a vital hallmark and prerequisite for microglia phenotype transition. Recently, histone lactylation was shown to promote macrophage homeostatic gene expression via transcriptional regulation. However, the role of histone lactylation in regulating microglia function in Parkinson’s disease (PD) remains unclear. Here, we...

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Literature Corpus work: d7812de6-a4f8-54f8-a97e-f5383fdccac6
DOI: 10.21203/rs.3.rs-3249462/v1

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