Article

The huntingtin–HAP40 complex is a bidirectional cellular rheostat

2026-06-08

Abstract excerpt

Huntingtin-associated protein 40 (HAP40) is an obligate structural subunit of huntingtin (HTT) and is rapidly degraded when unbound, yet has been conserved across eukaryotes for over a billion years. Combining interactomics, quantitative respirometry, and transcriptomics, we show that the HTT-HAP40 complex functions as a bidirectional stoichiometric rheostat: unbuffered apo-HAP40 activates the Integrated Stress Re...

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Literature Corpus work: 56baf175-f4a3-5e99-bd0c-51dd5910feb1
DOI: 10.64898/2026.06.03.729778

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